Clinician assists patient with negative pressure wound therapy for a diabetic foot ulcer

Negative Pressure Wound Therapy (NPWT)

Each patient and wound is unique and deserves customized care. 3M’s comprehensive negative pressure wound therapy solutions enable you to provide treatment options based on each patient’s need.


Reimagine wound care. One patient at a time.

The way you treat every patient is as unique as they are — and no two wounds, just like no two people, are exactly the same. With 3M’s scientifically engineered negative pressure wound therapy solutions and support, you can reimagine the way you approach wound care.


The 3M NPWT portfolio provides a wide range of wound management options, which have been shown in clinical studies to help reduce the cost of care and improve patient outcomes.1,2

How does NPWT work?

See the 3M™ V.A.C.® Therapy Mechanism of Action

3M V.A.C.® Therapy, one of the world leaders in negative pressure wound therapy, promotes an environment for wound healing by protecting the wound from external contamination, providing a moist wound environment, and promoting the formation of granulation tissue.3,4


The combination of a proprietary foam, drape, multi-lumen tubing, and advanced algorithms delivers a uniform negative pressure to the wound surface. This consistent negative pressure helps draw wound edges together, allows for the removal of exudate and infectious material, and stimulates the growth of tissue so the wound can heal.

Image shows how negative pressure wound therapy works at a wound site

  •  Illustration of wound edges with arrows showing edges moving together
    Draws wound edges together

    The application of uniform negative pressure induces a physical response — macrostrain — that can be seen immediately as the wound edges are drawn together, allowing for optimal contact between the wound bed and the dressing.

  • Illustration of exudate and infectious material from a wound
    Removes exudate and infectious material

    Macrostrain facilitates removal of wound exudate which may contain inhibitors of wound healing.

  • Image of blood vessels and tissue
    Reduces edema and promotes perfusion

    Removal of wound fluids assists in the reduction of edema, which facilitates the flow of blood into the wound bed, providing the oxygen and nutrients that are needed for wound healing.

  • Illustrations of wound tissue and dressing referring to granulation tissue formation
    Promotes granulation tissue formation

    In vitro/in vivo studies show that foam contact with tissue creates micro-deformation that leads to cell stretch.3 Cell stretch under negative pressure stimulates cellular activity that results in granulation tissue formation.4-5

    Over subsequent dressing changes, the granulation tissue fills the wound bed, further reducing the volume, and preparing it for final closure.

Explore NPWT in more depth

10 million wounds treated worldwide with V.A.C.® Therapy6

Since its introduction in 1995, V.A.C.® Therapy has been selected to treat more than 10 million wounds worldwide.6 More than 75% of published NPWT clinical evidence is based on 3M V.A.C.® Therapy.

Additional 3M Negative Pressure Wound Therapies

3M continues to develop new technologies and therapies designed to make wound healing manageable for caregivers and more comfortable for patients around the world. 3M Negative Pressure Wound Therapies are utilized across the continuum of care and come in a variety of shapes and sizes—ranging from a reusable therapy unit with multiple therapy modalities, to a portable and disposable unit that can fit in the palm of your hand.

Photo of Dermatac Drape providing a secure and effective NPWT seal on a wound

3M™ Dermatac™ Drape

Elevate the 3M™ V.A.C.® Therapy experience.
Applies with ease. Seals in the heal. Removes with kindness.

Changing your dressing each time shouldn’t cause additional pain. With Dermatac Drape, wound care patients will feel the difference of the first silicone-acrylic hybrid drape that is repositionable upon initial placement.

View all Dermatac products
gradient banner

Ready to give 3M NPWT products a try?

  • Contact 3M Dental Representative

    Contact us to request consultation with a 3M clinical specialist and a trial of 3M NPWT products.

    The information you provide on this form will be used to respond to your request through email or telephone by a 3M representative or by one of our authorised business partners with whom we might share your personal information consistent with the 3M privacy policy.

  • All fields are required unless indicated optional

  • 3M takes your privacy seriously. 3M and its authorized third parties will use the information you provided in accordance with our Privacy Policy to send you communications which may include promotions, product information and service offers. Please be aware that this information may be stored on a server located in the U.S. If you do not consent to this use of your personal information, please do not use this system.

  • Submit

Our apologies...

An error has occurred while submitting. Please try again later...

Thank you!

Your form was submitted successfully

  • NOTE: Specific indications, contraindications, warnings, precautions and safety information exist for these products and therapies. Please consult a clinician and product instructions for use prior to application. This material is intended for healthcare professionals.

    1. Law, A., Beach, K. Hospital stay costs associated with negative pressure wound therapy. Poster Presented at: Symposium on Advanced Wound Care(SAWC);October 16-18, 2014, Las Vegas, NV. 47(5):547-51.
    2. Law A L. Krebs B. Karnik B. Griffin L. Comparison of Healthcare Costs Associated With Patients Receiving Traditional Negative Pressure Wound Therapies in the Post Acute Setting. Cureus 12(11): e11790. DOI 10.7759/cureus.11790.
    3. Saxena V, Hwang CW, Huang S, Eichbaum Q, Ingber D, Orgill DP. Vacuum-assisted closure: microdeformations of wounds and cell proliferation. Plast Reconstr Surg 2004;114:1086-1096.
    4. McNulty AK, Schmidt M, Feeley T, Kieswetter K. Effects of negative pressure wound therapy on fibroblast viability, chemotactic signaling, and proliferation in a provisional wound (fibrin) matrix. Wound Repair Regen 2007;15:838- 846.
    5. McNulty AK, Schmidt M , Feeley T, Villanueva P, Kieswetter K. E ffects of negative pressure wound therapy on cellular energetics in fibroblasts grown in a provisional wound (fibrin) matrix. Wound Repair Regen 2009;17:192-199.
    6. Number of Wounds Treated by NPWT; Sources 2013‐2015: USA data from Orders report; includes USA and PR. ROW based on core KCI revenue report.
    7.  Gabriel A, Camardo M, O'Rorke E, Gold R, Kim PJ. Effects of Negative-Pressure Wound Therapy With Instillation versus Standard of Care in Multiple Wound Types: Systematic Literature Review and Meta-Analysis. Plast Reconstr Surg. 2021 Jan 1;147(1S-1):68S-76S. doi: 10.1097/PRS.0000000000007614. PMID: 33347065.
    8.  Kim PJ, Lookess S, Bongards C, Griffin LP, Gabriel A. Economic model to estimate cost of negative pressure wound therapy with instillation vs control therapies for hospitalised patients in the United States, Germany, and United Kingdom. Int Wound J. 2021 Sep 28. doi: 10.1111/iwj.13689. Epub ahead of print. PMID: 34582113.