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Monoclonal Antibody (mAb) and Recombinant Protein Manufacturing

Innovation for streamlined and accelerated workflows.

  • woman wearing a lab coat and gloves transferring liquid using a pipette

    Reimagine bioprocessing to accelerate speed to market

    Traditional bioprocessing lines can be challenging with outdated technology that can't keep up with new developments in higher-titer cell cultures and increased contaminants. We have a portfolio of solutions that can help your line run more efficiently and with excellent purity and higher yields.

Enabling high-performance single-stage clarification

process simplification infographic

Save valuable time without sacrificing quality. Take a traditional processing line and condense several steps into one with 3M's portfolio for mAb and recombinant protein clarification and purification.

  • streamline icon
    Streamlined handling of higher concentration cultures
  • efficiency icon
    Increased efficiency through reduced unit operations
  • reduction icon
    Reduced total cost of ownership

See the 3M difference

  • graph showing increase of yield by 29% when using 3M™ Harvest RC Chromatographic Clarifier and 3M™ Polisher ST
  • graph showing decrease in cost of 16% when using 3M™ Harvest RC Chromatographic Clarifier and 3M™ Polisher ST
  • Compare a legacy process consisting of two stages of depth filters during cell harvesting and traditional resin-based AEX and CEX columns in downstream polishing chromatography to a process using 3M™ Harvest RC Chromatographic Clarifier and 3M™ Polisher ST. This model shows a 29% increased yield and a 16% decreased cost.

    *Commercial Biosolve Process™ software package from Biopharm Services Limited was used for modeling. The results are generated for the hypothetical scenarios. Depending on product and process conditions, the effects shown here may not be realized or may not be realized to the degree shown in the scenarios. 3M data on file.

Next-generation process

infographic showing simplified bioprocess by incorporating 3M™ Harvest RC Chromatographic Clarifier and 3M™ Polisher ST products
    • 10x less HCP post-Protein A​
    • High mAb product recovery (>95%)​
    • Turbidity reduction <15 NTU
    • DNA reduction <500 ppb
    • Process intensification – process step compression​
    • HCP reduction >50% above pH 5​
    • Virus reduction >4 log​s
    • DNA clearance down to less than 10 ppb or reduction >4 logs or below detection​
    • High salt and low pH tolerance​
    • Platformability, works in a wide range of operating conditions

  • Cover of 3M Biopharmaceutical Clarification and Purification for mAb/Recombinant Protein

    Explore applications from 3M portfolio

    See how 3M solutions can be applied to your process.

  • Cover of Frost & Sullivan Webinar Summary – Next-Generation Biopharmaceutical Manufacturing Platforms

    Industry trends: Producing mAbs at a commercial scale

    • Biopharmaceutical products (biologics) are transforming the treatment of many diseases like cancer, rheumatoid arthritis (RA), Hepatitis C and Multiple Sclerosis (MS). Monoclonal antibodies (mAbs) and recombinant therapeutic proteins are the two largest biologics segments. Producing these molecules consistently at a commercial scale is both complex and costly.

      Frost & Sullivan has identified key trends driving biopharmaceutical companies to adopt a sandbox approach for development of next-generation biopharmaceutical manufacturing platforms. Read more in the webinar summary.

      Read the Frost & Sullivan Webinar Summary – Next-Generation Biopharmaceutical Manufacturing Platforms (PDF, 978 KB)

Want to simplify your process?

Innovation in cell culture production has created additional complexities for the clarification process. 3M offers single-stage and single-use solutions to help simplify your process and increase manufacturing efficiency.

Ask an expert

Fill out this form for any technical or process-related question, and an appropriate 3M Biopharmaceutical representative will contact you to answer your question or direct your request.

Educational Content

  • Green banner with vial icon, including the text 3M School of Purification

    3M School of Purification

    The 3M School Purification is a program designed by a team of 3M Technical Experts, with the purpose of educating the industry on a range of important biopharmaceutical separation and purification topics. The free initiative offers a variety of content and tools, available in a range of formats, to help you learn more about biopharmaceutical separation and purification.

    Learn more about 3M School of Purification

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