Are you interested in a cost-efficient, single-use and single-step option to streamline your process? This next-generation harvest and clarification technology:
3M Harvest RC enables a facility strategy that overcomes scale limitations and enables cost-efficient manufacturing with a full range of lab, pilot and manufacturing solutions to support the growing demand for biologics.
The newest 3M solution, 3M Harvest RC, utilises fibrous anion exchange (AEX) chromatography to efficiently separate cells, cell debris and DNA from the harvest fluid containing the target product. Precision quaternary ammonium (Q) functionalized polypropylene fibre, combined with a 0.2 µm PES membrane, provides predictable clarification that is scalable from discovery to commercial manufacturing.
3M™ Polisher ST is a fully encapsulated single-use anion exchange (AEX) product intended to reduce host cell protein impurities, viruses and other negatively charged contaminants in flow-through polishing chromatography.View all products
Are you interested in a cost-efficient, single-use and single-step option to streamline your process? Learn how to set up experiments for implementing 3M Harvest RC in your upstream process. Sign up for a virtual trial with a 3M application engineer.
3M Harvest RC enables a single-stage clarification process of high density cell culture (> 40 million cells per mL) with high recovery, and high fidelity of soluble and insoluble contaminant separation. Cells are bound inside the media by electrostatic charge interaction with the AEX chromatographic fibres. This results in the efficient retention of large and small particulates without developing a surface cake layer. The media can also remove soluble impurities which results in cleaner effluent than centrifugation or depth filtration.
Cell harvesting and clarification are both crucial steps that can have a significant impact on the design of downstream processes. As processes change upstream in the pharmaceutical manufacturing workflow, causing variability of cell culture fluid, downstream purification unit operations will be impacted.
Read an analysis by Frost & Sullivan on how 3M Harvest RC transforms the clarification process by replacing centrifuge and depth filtration steps, improves process efficiencies and scales effectively with a wide range of product formats.
Academic and industry leaders in biopharmaceutical manufacturing participated in a thought leadership forum, the Virtual Think Tank series, to discuss challenges, strategies, techniques, and barriers to new technology implementation in monoclonal antibody harvesting.
Find more detail about 3M Harvest RC, a new single-stage, single-use chromatographic clarification solution. It is designed as an efficient option to increase monoclonal antibody (mAb) yields while streamlining the upstream process by replacing the centrifuge and/or depth filtration process steps.
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A member of the 3M team will contact you within 48 hours to discuss details of the virtual trial for 3M Harvest RC.